Bulk Inquiry
JNJ 37822681 dihydrochloride
Axon 1802
- Parent CAS: 935776-74-2
Purity:
98%
- Soluble in water and DMSO
- MF: C17H17F5N4.2HCl
- MW: 445.26
Description
JNJ 37822681 dihydrochloride is a potent and selective dopamine D2 receptor antagonist described as a centrally acting, fast-dissociating D2 ligand.
D2 receptor blockade is central to antipsychotic pharmacology and dopaminergic regulation of motor, reward and neuroendocrine pathways. JNJ 37822681 is useful for studying D2 receptor occupancy, ligand binding kinetics and dopamine-dependent CNS signaling.
Key Features
- Selective dopamine D2 receptor antagonist
- Fast-dissociating centrally active D2 ligand
- Relevant to antipsychotic mechanism-of-action research
- Useful for probing dopaminergic receptor signaling
Applications
- Dopamine D2 receptor pharmacology
- CNS dopaminergic signaling studies
- Antipsychotic mechanism and receptor-occupancy research
- Ligand binding kinetics and functional receptor assays
More Information
| Parent CAS No. | 935776-74-2 |
|---|---|
| Chemical Name | N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-(trifluoromethyl)pyridazin-3-amine |
| SMILES | C1(F)C=CC(CN2CCC(NC3N=NC(C(F)(F)F)=CC=3)CC2)=CC=1F.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C17H17F5N4.2ClH/c18-13-2-1-11(9-14(13)19)10-26-7-5-12(6-8-26)23-16-4-3-15(24-25-16)17(20,21)22;;/h1-4,9,12H,5-8,10H2,(H,23,25);2*1H |
| InChiKey | UOLHGUUKFNZTNS-UHFFFAOYSA-N |
| CID | 91826482 |
| Short Description | D2 antagonist |
References
- X Langlois et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J. Pharmacol. Exp. Ther. 2012, 342(1), 91-105.
- ET te Beek et al. Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681. J. Psychopharmacol. 2012, 26(8), 1119-1127.
Related Products
Other Categories
Get a Quote for
Loading...