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Droperidol

 - R 4749  - Droleptan  - Dridol
Axon 1554
CAS:  548-73-2
Purity:  99%
  • Soluble in DMSO
  • MF:  C22H22FN3O2
  • MW:  379.43

Description

Droperidol is a dopamine D2 receptor antagonist with additional alpha-1 adrenergic receptor antagonist activity.

D2 receptor blockade underlies antiemetic and antipsychotic pharmacology, while adrenergic antagonism contributes to hemodynamic and sedative effects. Droperidol is useful as a reference compound in dopamine receptor, antiemetic and CNS safety pharmacology research.

Key Features

  • Dopamine D2 receptor antagonist
  • Additional alpha-1 adrenergic antagonist activity
  • Pharmacology relevant to antiemetic and antipsychotic mechanisms
  • Useful reference for CNS and cardiovascular safety studies

Applications

  • D2 receptor antagonist assays
  • Antiemetic mechanism research
  • Neuroleptic pharmacology studies
  • Cardiac/QT safety model evaluation

More Information

Parent CAS No. 548-73-2
Chemical Name 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
SMILES C1(C=CC(F)=CC=1)C(=O)CCCN1CC=C(N2C(=O)NC3C=CC=CC2=3)CC1
MFCD MFCD00083290
InChi InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
InChiKey RMEDXOLNCUSCGS-UHFFFAOYSA-N
CID 3168
Short Description D2/α1 antagonist

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