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(RS)-3,5-DHPG
- Soluble in water and DMSO
- MF: C8H9NO4
- MW: 183.16
Description
Selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. More specifically, the agonist activity is found only in its S-enantiomer, (S)-3,5-DHPG (Axon 1740) .
More Information
| Parent CAS No. | 146255-66-5 |
|---|---|
| Chemical Name | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
| SMILES | C1(O)C=C(O)C=C(C(C(=O)O)N)C=1 |
| MFCD | MFCD00272595 |
| InChi | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13) |
| InChiKey | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
| CID | 108001 |
| Short Description | mGluR1 agonist |
References
- I Ito et al. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport. 1992, 3(11), 1013-1016.
- DD Schoepp et al. 3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J. Neurochem. 1994, 63(2), 769-772.
- C Wiśniewski and H Car. (S)-3,5-DHPG: a review. CNS Drug Rev. 2002, 8(1), 101–116.
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