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LBH 589
- NVP-LBH 589 - Panobinostat
- Soluble in DMSO
- MF: C21H23N3O2
- MW: 349.43
Description
LBH 589 (Panobinostat) is a highly potent pan-HDAC inhibitor with reported subnanomolar activity against HDAC1.
Histone deacetylases regulate chromatin accessibility, transcription, cell-cycle control and apoptosis. LBH 589 is used to study epigenetic modulation, acetylation-dependent gene expression and antitumor responses in solid and hematologic cancer models.
Key Features
- Potent pan-HDAC inhibitor
- Reported HDAC1 IC50 around 0.23 nM
- Increases histone acetylation and alters transcriptional programs
- Relevant to apoptosis, differentiation and tumor growth research
Applications
- HDAC enzyme pharmacology
- Epigenetic gene-regulation studies
- Cancer cell apoptosis and differentiation assays
- Hematologic and solid tumor model research
More Information
| Parent CAS No. | 404950-80-7 |
|---|---|
| Chemical Name | (E)-N-Hydroxy-3-(4-{[2-(2-methyl-1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylamide |
| SMILES | N1C2C=CC=CC=2C(CCNCC2=CC=C(C=C2)/C=C/C(NO)=O)=C1C |
| MFCD | MFCD09833242 |
| InChi | InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ |
| InChiKey | FPOHNWQLNRZRFC-ZHACJKMWSA-N |
| CID | 6918837 |
| Short Description | HDAC inhibitor |
References
- P Maiso et al. The Histone Deacetylase Inhibitor LBH589 Is a Potent Antimyeloma Agent that Overcomes Drug Resistance. Cancer Res. 2006, 66(11), 5781-5789.
- AA Lane and BA Chabner. Histone Deacetylase Inhibitors in Cancer Therapy. J. Clin. Oncol. 2009, 27(32), 5459 - 5468.
- L Ellis et al. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 2009, 114(2), 380 - 393.
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