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Ropinirole hydrochloride
Axon 1514
- Parent CAS: 91374-21-9
Purity:
98%
- Soluble in water and DMSO
- MF: C16H24N2O.HCl
- MW: 296.84
Description
Ropinirole hydrochloride is a non-ergoline dopamine receptor agonist with activity at D2, D3 and D4 receptors, exhibiting the highest binding affinity at D3 subtype and highest functional relevance at D2/D3 signaling pathways.
Dopamine receptor agonism is central to research on basal ganglia circuitry, motor control, reward processing and dopaminergic therapeutics. Ropinirole is used as a reference agonist for studying D2-like receptor activation in CNS and pharmacology assays.
Key Features
- Non-ergoline dopamine D2-like receptor agonist
- Activity at D2, D3 and D4 dopamine receptors (binding affinity: D3 > D2 > D4)
- Pharmacology relevant to motor-control and reward pathways
- Useful comparator for dopaminergic therapeutic research
Applications
- Dopamine receptor pharmacology
- Parkinsonian motor pathway studies
- Basal ganglia signaling research
- D2-like receptor assay development
More Information
| Parent CAS No. | 91374-21-9 |
|---|---|
| Chemical Name | 4-(2-Dipropylamino-ethyl)-1,3-dihydro-indol-2-one |
| SMILES | Cl.C1(=O)NC2C=CC=C(CCN(CCC)CCC)C=2C1 |
| MFCD | MFCD01754173 |
| InChi | InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H |
| InChiKey | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
| CID | 68727 |
| Short Description | DA agonist |
Ropinirole hydrochloride
non-ergoline dopamine D2-like receptor agonist
Ropinirole
DRD4
DRD3
non-ergoline dopamine D2-like receptor
D3
Agonist
dopamine signaling
Dopamine receptor pharmacology
Parkinsonian motor pathway studies
Basal ganglia signaling research
D2-like receptor assay development
Parkinson's research
addiction research
GPCR pharmacology
signal transduction
receptor pharmacology
CNS
CAS 91374-21-9
CAS 91374-20-8
Axon Medchem
Axon 1514
Supplier
Vendor
References
- G. Gallagher Jr. et al. 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist. J. Med. Chem. 1985, 28, 1533-1536.
- S. Giménez-Roldán et al. Ropinirol: a new dopamine agonist in the treatment of Parkinson's disease. Neurologia. 1997, 12, 354-361.
- R.S. Kakar et al. Ropinirole in the treatment of restless legs syndrome. Expert Rev. Neurother. 2005, 5, 35-42.
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