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SB 203580 hydrochloride
- Parent CAS: 152121-47-6
- Soluble in water
- MF: C21H16FN3OS.HCl
- MW: 413.9
Description
Potent, cell-permeable and selective inhibitor of p38 MAP kinase (MAPK); water-soluble salt of SB 203580 (Axon 1363)
More Information
| Parent CAS No. | 152121-47-6 |
|---|---|
| Chemical Name | 4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride |
| SMILES | N1C=CC(C2NC(C3C=CC(S(=O)C)=CC=3)=NC=2C2C=CC(F)=CC=2)=CC=1.Cl |
| MFCD | MFCD00922198 |
| InChi | InChI=1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H |
| InChiKey | WOSGGXINSLMASH-UHFFFAOYSA-N |
| CID | 16760644 |
| Short Description | p38 MAPK inhibitor |
References
- PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
- PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
- H Kankaanranta et al. SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils. J. Pharm. Exp. Ther. 1999, 290, 2, 621-628.
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