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SB 203580
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H16FN3OS
- MW: 377.43
Description
Potent, cell-permeable and selective inhibitor of p38 MAP kinase (MAPK). Also available as its water-soluble form, SB 203580 hydrochloride (Axon 1465)
More Information
| Parent CAS No. | 152121-47-6 |
|---|---|
| Chemical Name | 4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-3H-imidazol-4-yl]-pyridine |
| SMILES | N1C=CC(C2NC(C3C=CC(S(=O)C)=CC=3)=NC=2C2C=CC(F)=CC=2)=CC=1 |
| MFCD | MFCD00922198 |
| InChi | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| InChiKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| CID | 176155 |
| Short Description | p38 MAPK inhibitor |
References
- PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
- PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
- H Kankaanranta et al. SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils. J. Pharm. Exp. Ther. 1999, 290, 2, 621-628.
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