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NNC 756
- Odapipam
Axon 1405
CAS:
131796-63-9
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C19H20ClNO2
- MW: 329.82
Description
NNC 756 (Odapipam) is a very high-affinity and selective dopamine D1 receptor antagonist with a reported receptor binding Kd value of 0.18 nM. It is more potent than SCH23390 (Axon 4341).
Odapipam blocks D1-like receptor signaling and has been used in receptor-occupancy and neuroimaging studies. It is a useful comparator for dopaminergic motor, cognitive and psychosis-related pathways.
Key Features
- High-affinity dopamine D1 receptor antagonist
- Reported Kd: 0.18 nM
- Suitable for D1 receptor occupancy studies
- Greater D1 antagonist potency than many classical references
Applications
- D1 receptor binding and functional assays
- Dopamine receptor occupancy research
- Motor and cognitive pathway studies
- Psychosis and antipsychotic pharmacology models
More Information
| Parent CAS No. | 131796-63-9 |
|---|---|
| Chemical Name | (S)-(+)-8-Chloro-5-(2,3-dihydro-benzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol |
| SMILES | [C@@H]1(C2C3OCCC=3C=CC=2)C2C=C(O)C(Cl)=CC=2CCN(C)C1 |&1:0,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1 |
| InChiKey | SKMVRXPBCSTNKE-MRXNPFEDSA-N |
| CID | 132421 |
| Short Description | D1 antagonist |
References
- EB Nielsen, PH Andersen. Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. Eur. J. Pharmacol. 1992, 219(1), 35-44; ibid 45-52.
- A Abi-Dargham et al. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999, 32(2), 93-109.
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