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YM 298198 hydrochloride
- Parent CAS: 748758-45-4
- Soluble in water and DMSO
- MF: C18H22N4OS.HCl
- MW: 378.92
Description
Selective mGlu1 antagonist. Its derivative, Desmethyl YM-298198 (Axon 1259) is also available.
More Information
| Parent CAS No. | 748758-45-4 |
|---|---|
| Chemical Name | 6-Amino-3-methyl-benzo[4,5]imidazo[2,1-b]thiazole-2-carboxylic acid cyclohexyl-methyl-amide hydrochloride |
| SMILES | C1C=C2N=C3SC(C(N(C)C4CCCCC4)=O)=C(C)N3C2=CC=1N.Cl |
| MFCD | MFCD08703122 |
| InChi | InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H |
| InChiKey | WYTJVUVCSUWZTH-UHFFFAOYSA-N |
| CID | 45073464 |
| Short Description | mGluR1 antagonist |
References
- Fukunaga et al. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br. J. Pharmacol. 2007, 151(6), 870-876.
- Kohara et al. Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198). J. Pharmacol. Exp. Ther. 2005, 315, 163.
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