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BMS 605541
- Soluble in DMSO
- MF: C19H17F2N5OS
- MW: 401.43
Description
BMS-605541 is a potent, selective, orally active and ATP-competitive inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2/KDR) with an IC50 value of 23 nM. It suppresses VEGF-dependent receptor phosphorylation and downstream endothelial signaling.
BMS-605541 is used to investigate VEGFR2-driven angiogenesis, endothelial proliferation and tumor vascularization. Oral activity has been demonstrated in human lung and colon carcinoma xenograft models, supporting use in pharmacodynamic and antiangiogenic studies.
Key Features
- Potent ATP-competitive VEGFR2 inhibitor
- IC50: 23 nM
- Selective and orally active
- Inhibits tumor growth in xenograft models
Applications
- VEGFR2 kinase research
- VEGF signaling assays
- Endothelial proliferation studies
- Angiogenesis models
- Tumor vascularization research
More Information
| Parent CAS No. | 639858-32-5 |
|---|---|
| Chemical Name | N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide |
| SMILES | C1(F)C=C(F)C(C(=O)NC2CC2)=CC=1NCC1SC(NC2C=CC=CN=2)=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) |
| InChiKey | CUPLTRAPYIXFAX-UHFFFAOYSA-N |
| CID | 11632737 |
| Short Description | VEGFR2 inhibitor |
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