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ZM 323881 hydrochloride
- Parent CAS: 193001-14-8
- Soluble in DMSO
- MF: C22H18FN3O2.HCl
- MW: 411.86
Description
ZM 323881 hydrochloride is a potent and selective VEGFR2/KDR inhibitor with reported IC50 activity of 2 nM for VEGFR2. It provides strong inhibition of VEGF-driven endothelial receptor tyrosine kinase signaling.
VEGFR2 is the principal mediator of VEGF-dependent angiogenesis, endothelial proliferation and vascular permeability. ZM 323881 is useful for dissecting VEGFR2-selective signaling in angiogenesis, oncology and vascular biology models.
Key Features
- Potent VEGFR2/KDR inhibitor
- Reported IC50: 2 nM for VEGFR2
- Selectively blocks VEGF-driven endothelial signaling
- Relevant to angiogenesis and vascular pharmacology
Applications
- VEGFR2 kinase assays
- Angiogenesis research
- Endothelial cell signaling studies
- Antiangiogenic oncology models
More Information
| Parent CAS No. | 193001-14-8 |
|---|---|
| Chemical Name | 5-(7-(benzyloxy)quinazolin-4-ylamino)-4-fluoro-2-methylphenol hydrochloride |
| SMILES | C1(O)=CC(NC2=C3C(=NC=N2)C=C(OCC2=CC=CC=C2)C=C3)=C(F)C=C1C.Cl |
| MFCD | MFCD08703130 |
| InChi | InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H |
| InChiKey | AVRHWGLIYGJSOD-UHFFFAOYSA-N |
| CID | 22624897 |
| Short Description | VEGFR2 inhibitor |
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