CMP5 is a selective PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Also CMP5 inhibited Th1 cell proliferation (IC50 value 3.7 μM) more potently than Th2 cell proliferation (IC50 value 9.2 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.

Also the more potent and bioavailable derivative HLCL65 hydrochloride is available (Axon 2710).

KEYWORDS: CMP5 | supplier | PRMT5 inhibitor | CMP 5 | CMP-5 | CAS [1030021-40-9] | [880813-42-3] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes