CMP5

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2709

CAS [1030021-40-9]

MF C20H22N3.HCl
MW 351.87

  • Purity: 99%
  • Soluble in water and DMSO
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CMP5

Description

CMP5 is a selective PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Also CMP5 inhibited Th1 cell proliferation (IC50 value 3.7 μM) more potently than Th2 cell proliferation (IC50 value 9.2 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.

Also the more potent and bioavailable derivative HLCL65 hydrochloride is available (Axon 2710).

KEYWORDS: CMP5 | supplier | PRMT5 inhibitor | CMP 5 | CMP-5 | CAS [1030021-40-9] | [880813-42-3] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes

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10 mg €95.00 In Stock
50 mg €325.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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