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Axon 2709
CAS [1030021-40-9]
MF C20H22N3.HClMW 351.87
CMP5 is a selective PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Also CMP5 inhibited Th1 cell proliferation (IC50 value 3.7 μM) more potently than Th2 cell proliferation (IC50 value 9.2 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.
Also the more potent and bioavailable derivative HLCL65 hydrochloride is available (Axon 2710).
KEYWORDS: CMP5 | supplier | PRMT5 inhibitor | CMP 5 | CMP-5 | CAS [1030021-40-9] | [880813-42-3] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes
1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine hydrochloride
[880813-42-3]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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