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HLCL65 hydrochloride
- Parent CAS: 1627865-11-5
- Soluble in DMSO
- MF: C23H23BrN2O.HCl
- MW: 459.81
Description
HLCL65 is a highly selective small molecule PRMT5 inhibitor. HLCL65 inhibited Th1 cell proliferation (IC50 value 1.1 μM) more potently than Th2 cell proliferation (IC50 value 4 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.
HLCL65 is a more potent and bioavailable derivative of CMP5 (Axon 2709).
More Information
| Parent CAS No. | 1627865-11-5 |
|---|---|
| Chemical Name | 1-(6-Bromo-9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride |
| SMILES | C12C=C(Br)C=CC=1N(CC)C1C=CC(CNCC3C(OC)=CC=CC=3)=CC2=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C23H23BrN2O.ClH/c1-3-26-21-10-8-16(12-19(21)20-13-18(24)9-11-22(20)26)14-25-15-17-6-4-5-7-23(17)27-2;/h4-13,25H,3,14-15H2,1-2H3;1H |
| InChiKey | RCHOCKASSZYCEX-UHFFFAOYSA-N |
| CID | 129909864 |
| Short Description | PRMT5 inhibitor |
References
- D El-Gamal et al. Expression of PRMT5 in B-Cell Chronic Lymphocytic Leukemia and Its Significance in Disease Progression and Richter's Transformation. Blood 2014 124:2197.
- LM Webb et al. Protein Arginine Methyltransferase 5 (PRMT5) Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol 198 (4), 1439-1451. 2017 Jan 13.
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