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CMP5
- Parent CAS: 880813-42-3
- Soluble in water and DMSO
- MF: C21H22ClN3
- MW: 351.87
Description
CMP5 is a selective PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Also CMP5 inhibited Th1 cell proliferation (IC50 value 3.7 μM) more potently than Th2 cell proliferation (IC50 value 9.2 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.
Also the more potent and bioavailable derivative HLCL65 hydrochloride is available (Axon 2710).
More Information
| Parent CAS No. | 880813-42-3 |
|---|---|
| Chemical Name | 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine hydrochloride |
| SMILES | C12C=C(CNCC3N=CC=CC=3)C=CC=1N(CC)C1C=CC=CC2=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C21H21N3.ClH/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17;/h3-13,22H,2,14-15H2,1H3;1H |
| InChiKey | LTMOFUKBECEABM-UHFFFAOYSA-N |
| CID | 6462334 |
| Short Description | PRMT5 inhibitor |
References
- L Alinari et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43.
- LM Webb et al. Protein Arginine Methyltransferase 5 (PRMT5) Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol 198 (4), 1439-1451. 2017 Jan 13.
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