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FH535 sodium salt
- Parent CAS: 108409-83-2
- Soluble in water and DMSO
- MF: C13H9Cl2N2NaO4S
- MW: 383.18
Description
Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines; water soluble sodium salt form of FH535 (Axon 2686).
More Information
| Parent CAS No. | 108409-83-2 |
|---|---|
| Chemical Name | Sodium (2,5-dichlorophenylsulfonyl)(2-methyl-4-nitrophenyl)amide |
| SMILES | C1C=C(Cl)C(S(=O)(=O)[N-]C2C(C)=CC([N+]([O-])=O)=CC=2)=CC=1Cl.[Na+] |
| MFCD | N.A. |
| InChi | InChI=1S/C13H9Cl2N2O4S.Na/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15;/h2-7H,1H3;/q-1;+1 |
| InChiKey | KUOWFVORCZBNQF-UHFFFAOYSA-N |
| CID | 129909863 |
| Short Description | Dual Wnt/β-catenin and PPAR inhibitor |
References
- S Handeli et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7(3):521-9.
- R Gedaly et al. Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One. 2014 Jun 18;9(6):e99272.
- J Iida et al. FH535 inhibited migration and growth of breast cancer cells. PLoS One. 2012;7(9):e44418.
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