Based on 94 publications in PubMed 10 10 94

Axon 2686

CAS [108409-83-2]

MF C13H10Cl2N2O4S
MW 361.20

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO



Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706.

KEYWORDS: FH535 | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 | FH 535 | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef

Size Unit Price Stock
10 mg €75.00 In Stock
50 mg €295.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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