Bulk Inquiry
FH535
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C13H10Cl2N2O4S
- MW: 361.2
Description
Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines. The water soluble sodium salt of FH535 is available as Axon 2706.
More Information
| Parent CAS No. | 108409-83-2 |
|---|---|
| Chemical Name | 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide |
| SMILES | C1C=C(Cl)C(S(=O)(=O)NC2C(C)=CC([N+]([O-])=O)=CC=2)=CC=1Cl |
| MFCD | MFCD01212888 |
| InChi | InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3 |
| InChiKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| CID | 3463933 |
| Short Description | Dual Wnt/β-catenin and PPAR inhibitor |
References
- S Handeli et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7(3):521-9.
- R Gedaly et al. Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One. 2014 Jun 18;9(6):e99272.
- J Iida et al. FH535 inhibited migration and growth of breast cancer cells. PLoS One. 2012;7(9):e44418.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1227 | WY 14643 |
From $55.00 |
| 1237 | GW 7647 |
From $104.50 |
| 1567 | KRP 297 |
From $121.00 |
| 1628 | GSK 3787 |
From $99.00 |
| 1766 | ICG 001 |
From $126.50 |
| 1950 | CDDO |
From $88.00 |
| 2019 | INT131 |
From $99.00 |
| 2036 | KY 02111 |
From $88.00 |
| 2084 | SKL 2001 |
From $99.00 |
| 2114 | CP 775146 |
From $121.00 |
| 2120 | Wnt agonist 1 |
From $99.00 |
| 2133 | iCRT5 |
From $99.00 |
| 2135 | iCRT14 |
From $143.00 |
| 2161 | CCT 031374 hydrobromide |
From $66.00 |
| 2188 | WAY 262611 dihydrochloride |
From $137.50 |
| 2262 | GW 9662 |
From $66.00 |
| 2325 | WAY 316606 hydrochloride |
From $93.50 |
| 2443 | Rosiglitazone |
From $104.50 |
| 2533 | Hydroxypioglitazone |
From $198.00 |
| 2706 | FH535 sodium salt |
From $88.00 |
| 2727 | Elafibranor |
From $99.00 |
| 2814 | MHY 553 |
From $104.50 |
| 3715 | E-7386 |
From $275.00 |
| 3999 | Saroglitazar magnesium |
From $176.00 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.