Pexidartinib - PLX 3397

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2501

CAS [1029044-16-3]

MF C20H15ClF3N5
MW 417.81

Purity: 99%
Soluble in DMSO

Pexidartinib

Description

Multi-targeted receptor tyrosine kinase inhibitor of CSF1R, c-Kit, and FLT3 (IC50 values 13 nM, 27 nM, and 11 nM, respectively) Administration of PLX3397 reduced CIBP, induced substantial intratumoral fibrosis, and was also highly efficacious in reducing tumor cell growth, formation of new tumor colonies in bone, and pathological tumor-induced bone remodeling. PLX3397 is superior to imatinib in the treatment of malignant peripheral nerve sheath tumor (MPNST), and the combination of PLX3397 with a TORC1 inhibitor could provide a new therapeutic approach for the treatment of this disease.

C.C. Smith et al. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun;5(6):668-79.

P.P. Patwardhan et al. Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and rapamycin as a potential new approach for the treatment of MPNSTs. Clin Cancer Res. 2014 Jun 15;20(12):3146-58.

T.S. Kim et al. Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clin Cancer Res. 2014 May 1;20(9):2350-62.

M.L. Thompson et al. Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer. Pain. 2015 Sep;156(9):1692-702.

Angiogenesis Cell Signaling & Oncology CNS Stem Cell FLT3 TGF-β MAPK JAK-STAT PI3K-Akt-mTOR c-KIT RTK class III and IV; EC 2.7.10.1 CSF1R

Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3

Chemical name

5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

Parent CAS No.

[1029044-16-3]

Order

Size	Unit Price	Stock
10 mg	€60.00	In Stock
50 mg	€180.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1368	PD 184352	MEK 1 inhibitor	€80.00
1394	Imatinib mesylate	Bcr-Abl, c-KIT and PDGFR kinase inhibitor	€60.00
1398	Sunitinib malate	Multi-targeted receptor tyrosine kinase inhibitor	€80.00
1414	AG 013736	PDGFR,c-KIT and VEGFR tyrosine kinase inhibitor	€50.00
1415	CT 53518	PDGFR, c-KIT and FLT3 tyrosine kinase inhibitor	€70.00
1419	AB 1010	PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor	€70.00
1420	Pazopanib hydrochloride	PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor	€60.00
1547	OSI 930	c-Kit and VEGFR2 tyrosine kinase inhibitor	€90.00
1581	SU 11274	ATP-competitive inhibitor of c-MET	€90.00
1582	Foretinib	c-MET and VEGFR2 tyrosine kinase inhibitor	€90.00
1583	PF 04217903 mesylate	c-MET tyrosine kinase Inhibitor	€80.00
1638	ABT 869	PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor	€85.00
1660	PF 02341066	c-MET Inhibitor; NPM-ALK inhibitor	€80.00
1678	Regorafenib	Multi-kinase RTK inhibitor	€70.00
1696	AC 220 dihydrochloride	FLT3 inhibitor	€90.00
1768	AMG 706	Multiple receptor tyrosine kinase inhibitor	€105.00
1819	Cabozantinib S-malate	Inhibitor of multiple receptor tyrosine kinases, specifically MET and VEGFR2	€60.00
1838	ARQ 197	c-MET tyrosine kinase Inhibitor	€90.00
1891	SU 6668	Inhibitor of RTK targeting PDGFR, VEGF and FGFR	€100.00
1914	SGX 523	ATP-competitive inhibitor of c-MET	€120.00
1916	AMG 208	Inhibitor of c-MET receptor tyrosine kinase (RTK)	€95.00
1959	Golvatinib	Potent and orally available inhibitor of c-MET (HGFR) and VEGFR2	€90.00
2368	Amuvatinib	RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met	€105.00
2647	Pirfenidone	Broad-spectrum anti-inflammatory and anti-fibrosis agent	€60.00
2800	Ensemble Compound 159	Cytokine inhibitor; IL-17A inhibitor	Inquire
2767	SU11652	Multi-targeted receptor tyrosine kinase inhibitor	€140.00
3054	PLX5622	Potent, specific, orally bioavailable and brain-penetrant inhibitor of CSF1R	€80.00
3165	Lenvatinib	Multi-targeted receptor tyrosine kinase inhibitor	€70.00
3428	CSF1R inhibitor compound 22	Potent, cellular active and orally bioavailable CSF1R inhibitor	€130.00
3624	Toceranib phosphate	Multi-targeted receptor tyrosine kinase inhibitor	€60.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

Pexidartinib - PLX 3397

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Pexidartinib - PLX 3397

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us