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Axon 2300
CAS [1616632-77-9]
MF C24H26N4OMW 386.49
Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. Dordaviprone/ONC2101 is the "TIC10 active isomer" (Angular TIC10) inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent. Analog ONC212 (Axon 3581) is also available.
Prime Source Information: Axon 2300 is the confirmed 'angular' bio-active regio-isomer '2' as identified in the recently published article of Angew. Chem. 2014, 126, 6746 –6749! Thus it used to be called "TIC10 active isomer or Angular TIC10".
Keywords: Dordaviprone | TRAIL activator | ONC201 | TIC10 active isomer | Angular TIC10 | ONC-201 | ONC 201 | TIC-10 | TIC 10 | CAS [1616632-77-9] | TNF-α | TRAIL | Activator | Proteins | Active isomer 2 | p53 | Akt | ERK | translocation | Foxo3a
7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
[1616632-77-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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