TIC10 active isomer - ONC201 | Angular TIC10

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2300

CAS [1616632-77-9]

MF C24H26N4O
MW 386.49

  • Purity: 99%
  • Soluble in DMSO

TIC10 active isomer


Potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10/ONC201 inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. Efficacious antitumor therapeutic agent. Analog ONC212 (Axon 3581) is also available.

Prime Source Information:
Axon 2300 is the confirmed 'angular' bio-active regio-isomer '2' as identified in the recently published issue of Angew. Chem. 2014, 126, 6746 –6749!

KEYWORDS: TIC10 active isomer | supplier | TRAIL activator | ONC201 | Angular TIC10 | Active isomer 2 | CAS [1616632-77-9] | TNF-α | TRAIL | p53 | Akt | ERK | translocation | Foxo3a

Size Unit Price Stock
10 mg €120.00 In Stock
50 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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