Deltarasin trihydrochloride

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2284

CAS [1440898-82-7]

MF C40H37N5O.3HCl
MW 713.14

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

Deltarasin trihydrochloride

Description

Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS.
Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.

Chemical name

(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride

Parent CAS No.

[1440898-61-2]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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