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Levofloxacin Q-acid
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C13H9F2NO4
- MW: 281.21
Description
Inhibitor of bacterial DNA gyrase and topoisomerase IV with a minimum inhibitory concentration (MIC) of 0.75 μg/mL against penicillin-resistant Streptococcus pneumoniae.
Analogue of Trovafloxacin (Axon 2100).
More Information
| Parent CAS No. | 100986-89-8 |
|---|---|
| Chemical Name | (S)-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid |
| SMILES | O1C2=C(F)C(F)=CC3C(=O)C(C(O)=O)=CN(C2=3)[C@@H](C)C1 |&1:17,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C13H9F2NO4/c1-5-4-20-12-9(15)8(14)2-6-10(12)16(5)3-7(11(6)17)13(18)19/h2-3,5H,4H2,1H3,(H,18,19)/t5-/m0/s1 |
| InChiKey | NVKWWNNJFKZNJO-YFKPBYRVSA-N |
| CID | 688333 |
| Short Description | Topo IV inhibitor |
References
- B. Guruswamy et al. Synthesis, Characterization, Antimicrobial Activity of Novel N-Substituted ß-Hydroxy Amines and ß-Hydroxy Ethers Contained Chiral Benzoxazine Fluoroquinolones. Lett. Drug Design & Discov. 2013, 10, 86-93.
- E. Hershberger et al. Activities of trovafloxacin, gatifloxacin, clinafloxacin, sparfloxacin, levofloxacin, and ciprofloxacin against penicillin-resistant Streptococcus pneumoniae in an (...). Antimicrob. Agents Chemother. 2000, 44, 598-601.
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