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Irinotecan hydrochloride
- CPT-11 - Camptothecin 11
- Parent CAS: 97682-44-5
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C33H38N4O6.HCl
- MW: 623.14
Description
Irinotecan hydrochloride is the prodrug for SN-38, which is a topoisomerase I inhibitor. SN-38 has demonstrated potent growth inhibition of human colorectal cancer cells in vitro, with superior activity to fluorouracil.
More Information
| Parent CAS No. | 97682-44-5 |
|---|---|
| Chemical Name | [(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate hydrochloride |
| SMILES | C1CCN(C2CCN(C(=O)OC3C=C4C(CC)=C5CN6C(=O)C7COC(=O)[C@](O)(CC)C=7C=C6C5=NC4=CC=3)CC2)CC1.Cl |&1:27,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1 |
| InChiKey | GURKHSYORGJETM-WAQYZQTGSA-N |
| CID | 74990 |
| Short Description | Topo 1 inhibitor |
References
- LR Wiseman et al. Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs. 1996 Oct;52(4):606-23.
- FM de Man et al. Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics. Clin Pharmacokinet. 2018 Oct;57(10):1229-1254.
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