DNA Topoisomerase

Topoisomerases are a family of enzymes that catalyze the unwinding and unknotting of DNA sequences. By introducing transient 'nicks', these enzymes can relieve the topological pile-up of DNA that is caused by processes such as replication and transcription. DNATopoisomerase I (Topo1; EC. regulates the overwinding or underwinding of DNA in an ATP-independent manner. It binds to single-stranded DNA and cuts the phosphate backbone of the DNA. This intermediate break allows the DNA to be untangled or unwound, and, at the end of these processes, the DNA backbone is resealed again. Since the overall chemical composition and connectivity of the DNA do not change, the tangled and untangled DNAs are chemical isomers, differing only in their global topology[1].

[1] DNA topoisomerases: structure, function, and mechanism. J.J. Champoux. Annu. Rev. Biochem. 2001, 70, 369-413.

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Axon ID Name Description From price
1687 (±)-E-Homocamptothecin Potent topoisomerase I (Topo 1) inhibitor €120.00
3220 ARN24139 Orally active topoisomerase II poison €130.00
2391 CS1 TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects €135.00
4072 Doxorubicin hydrochloride A cytotoxic anthracycline antibiotic Inquire
3171 Gatifloxacin hydrochloride Inhibitor of bacterial DNA gyrase and topoisomerase IV €50.00
2198 Genz 644282 Topo I inhibitor lacking MDR1 and BCRP affinity €95.00
3370 Irinotecan hydrochloride Prodrug of SN-38; Topoisomerase I (Topo 1) inhibitor €80.00
2242 Levofloxacin Q-acid Inhibitor of bacterial DNA gyrase and topoisomerase IV €55.00
2914 TAS-103 dihydrochloride Dual inhibitor of topoisomerase I (Topo 1) and topoisomerase II (Topo 2) €95.00
2100 Trovafloxacin mesylate Inhibitor of bacterial DNA gyrase and Topo IV €110.00

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