Bulk Inquiry
(±)-E-Homocamptothecin
- dl-hCPT - BN 80245
- Moderately soluble in DMSO
- MF: C21H18N2O4
- MW: 362.38
Description
(±)-E-Homocamptothecin is a potent topoisomerase I (Topo I/TOPO1) inhibitor and E-ring-modified camptothecin analogue with enhanced chemical stability.
Topoisomerase I inhibitors stabilize DNA cleavage complexes, causing replication-associated DNA damage and apoptosis. (±)-E-Homocamptothecin is useful for investigating camptothecin-like pharmacology, DNA damage responses and antitumor mechanisms.
Key Features
- Potent topoisomerase I inhibitor
- E-ring-modified camptothecin analogue
- Enhanced stability compared with camptothecin scaffolds
- Induces DNA damage-associated apoptotic responses
Applications
- Topo I enzyme and cell-based assays
- DNA damage response research
- Apoptosis and cell-cycle studies
- Anticancer compound profiling
More Information
| Parent CAS No. | 186668-40-6 |
|---|---|
| Chemical Name | 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-1,4,5,13-tetrahydro-5-hydroxy- |
| SMILES | C1C=C2C=C3CN4C(=CC5C(O)(CC)CC(=O)OCC=5C4=O)C3=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H18N2O4/c1-2-21(26)9-18(24)27-11-14-15(21)8-17-19-13(10-23(17)20(14)25)7-12-5-3-4-6-16(12)22-19/h3-8,26H,2,9-11H2,1H3 |
| InChiKey | PAEZRCINULFAGO-UHFFFAOYSA-N |
| CID | 9863779 |
| Short Description | Topo 1 inhibitor |
References
- L Lesueur-Ginot et al. Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties. Cancer Res. 1999, 59(12), 2939-2943.
- O Lavergne et al. Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues. J. Med. Chem. 1998, 41(27), 5410–5419.
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