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HAMNO
- NSC 111847
- Soluble in DMSO
- MF: C17H13NO2
- MW: 263.29
Description
HAMNO (NSC111847) is a protein-interaction inhibitor of replication protein A (RPA) that selectively binds the N-terminal DBD-F domain of RPA70. It disrupts critical RPA protein interactions and inhibits ATR autophosphorylation and ATR-mediated phosphorylation of RPA32 Ser33.
RPA coordinates single-stranded DNA protection, replication stress signaling and ATR/Chk1 checkpoint activation. HAMNO is useful for studying RPA-dependent replication stress responses and cancer-cell vulnerability to oncogene-induced DNA damage.
Key Features
- RPA protein-interaction inhibitor
- Binds the RPA70 N-terminal DBD-F domain
- Inhibits ATR autophosphorylation
- Suppresses ATR-mediated RPA32 Ser33 phosphorylation
Applications
- Replication stress research
- RPA interaction studies
- ATR/Chk1 pathway assays
- DNA damage response and cancer vulnerability models
More Information
| Parent CAS No. | 138736-73-9 |
|---|---|
| Chemical Name | 1-((2-Hydroxyphenylamino)methylene)naphthalen-2(1H)-one |
| SMILES | C1(=C/NC2=CC=CC=C2O)C2=C(C=CC=C2)C=CC1=O |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13NO2/c19-16-10-9-12-5-1-2-6-13(12)14(16)11-18-15-7-3-4-8-17(15)20/h1-11,18,20H/b14-11- |
| InChiKey | NADCEWZYITXLKJ-KAMYIIQDSA-N |
| CID | 85895 |
| Short Description | RPA inhibitor |
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