Isomerases

From a mechanistic point of view, isomerases are enzymes that catalyze the structural rearrangement of isomers. Five subclasses are recognized by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the nomenclature and classification of enzymes. Cyclophilin A (CypA; EC 5.2.1.8) is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. They are known to bind to cyclosporine, an immunosuppressant which is usually used to suppress rejection after internal organ transplants.  More specifically, the cyclosporin-cyclophilin A complex inhibits a calcium/calmodulin-dependent phosphatase, calcineurin, the inhibition of which is thought to halt the production of the pro-inflammatory molecules interleukin 2 and TNF alpha[1].


[1] The cyclophilins. P. Wang, J. Heitman. Genome Biol. 2005, 6, 226.

7 Item(s)

per page
Axon ID Name Description From price
2391 CS1 TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects €135.00
1166 DC 838 CypA inhibitor €135.00
2198 Genz 644282 Topo I inhibitor lacking MDR1 and BCRP affinity €95.00
1687 Homocamptothecin, (±)-E- Potent topoisomerase I (Topo 1) inhibitor €135.00
2242 Levofloxacin Q-acid Inhibitor of bacterial DNA gyrase and topoisomerase IV €55.00
2020 PF 4693627 Selective and orally bioavailable inhibitor of mPGES-1 €125.00
2100 Trovafloxacin mesylate Inhibitor of bacterial DNA gyrase and Topo IV €105.00

7 Item(s)

per page
Please wait...