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Topobexin
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C29H35N3O4
- MW: 489.61
Description
Topobexin is a highly potent and TOP2B-selective catalytic inhibitor with an IC50 value of 0.19 μM (DNA decatenation assay). Topobexin provides potent cardioprotective effects against anthracycline-induced cardiotoxicity (AIC) - both in vitro in primary cardiomyocytes and in vivo in a well-established chronic AIC rabbit model.
More Information
| Parent CAS No. | 3076446-44-8 |
|---|---|
| Chemical Name | (7-(2-(4-Methyl-1-piperazinyl)ethoxy)-4-propyl-8-coumarinyl)(1,2,3,4-tetrahydro-1-quinolyl)methanone |
| Short Description | TOP2B inhibitor |
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