Stem Cell Alternative 2i inhibitor Set

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2130

CAS [N.A.]

MF N.A.
MW N.A.

  • Purity: 99%
  • Soluble in DMSO

Stem Cell Alternative 2i inhibitor Set

Description

A convenient set of SRC inhibitor CGP 77675 (Axon 2097) and GSK-3 inhibitor CHIR 99021 (Axon 1386); an alternative 2i inhibitor set vs the conventional 2i inhibitor set (Axon 2128) of MEK inhibitor PD 0325901 and GSK3 inhibitor CHIR 99021.

The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 (termed alternative 2i) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos.

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Each 2 mg €110.00 In Stock
Each 5 mg €150.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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