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Stem Cell Alternative 2i inhibitor Set
Set of 2 Inhibitors
CGP 77675 (Axon 2097)
CHIR99021 (Axon 1386)
(2 mg or 5 mg of each inhibitor)
* Two Inhibitors are in powder form (high purity: 99%)
Ready to be reconstituted freshly
to their 10 mM solutions in DMSO respectively.
Expert Recommendation!
Description
A convenient set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386); an alternative 2i inhibitor set vs the conventional 2i inhibitor set (Axon 2128) of MEK inhibitor PD0325901 and GSK-3 inhibitor CHIR99021. The dual inhibition of Src and GSK-3 signaling by CGP77675 and CHIR99021 (termed alternative 2i) was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD0325901 and CHIR99021 (conventional 2i, Axon 2128). This alternative 2i method provides a versatile tool not only for the maintenance of mESCs in serum-free conditions but also for the derivation of ESCs from mouse embryos.
Read more: Additional Product Information
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More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N.A. |
| MFCD | N.A. |
| Short Description | Stem cell inhibitor set |
References
- T. Shimizu et al. Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling. Stem Cells 2012, 30, 1394-1404.
- List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem
- List of publications using CGP 77675 (Axon 2097) purchased from Axon Medchem
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