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JW 55

Axon 1922
CAS:  664993-53-7
Purity:  99%
  • Soluble in DMSO
  • MF:  C25H26N2O5
  • MW:  434.48

Description

A tankyrase (TNKS) inhibitor, inhibiting PARP domain of TNKS1 and TNKS2; JW55 inhibits canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice

More Information

Parent CAS No. 664993-53-7
Chemical Name N-(4-((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methylcarbamoyl)phenyl)furan-2-carboxamide
SMILES O1C=CC=C1C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)=O
MFCD N.A.
InChi InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
InChiKey ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
CID 2946601
Short Description TNKS1/2 inhibitor

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