GSK 461364

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1688

CAS [929095-18-1]

MF C27H28F3N5O2S
MW 543.60

Purity: 99%
Optical purity: 99% ee
Soluble in DMSO

GSK 461364

Description

Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (Ki: 2.2 nM) over PLK2 and PLK3.

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

PLK1 inhibitor

Chemical name

(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Parent CAS No.

[929095-18-1]

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Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€360.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€540.00	In Stock

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GSK 461364

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Description

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