GSK 461364 analogue II

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1626

CAS [929095-22-7]

MF C27H27F3N4O3S
MW 544.59

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

GSK 461364 analogue II

Description

Potent Polo-like kinase (PLK) inhibitor, selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 270 nM)

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

PLK1 Inhibitor

Chemical name

(R)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Parent CAS No.

[929095-22-7]

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5 mg	€130.00	In Stock
25 mg	€460.00	In Stock

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GSK 461364 analogue II

Description

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Parent CAS No.

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GSK 461364 analogue II

Description

Chemical name

Parent CAS No.

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