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Pridopidine hydrochloride
- ACR16 hydrochloride
- Parent CAS: 346688-38-8
- Soluble in water and DMSO
- MF: C15H23NO2S.HCl
- MW: 317.87
Description
Pridopidine hydrochloride (ACR16) is a dopaminergic stabilizer with high-interest pharmacology at the sigma-1 receptor and modulatory effects on dopamine D2 receptor-dependent behavior.
Pridopidine is relevant to movement-disorder and neurodegeneration research because it can normalize state-dependent psychomotor activity and engage pathways linked to neuronal stress adaptation. It is used to study sigma-1 receptor biology, dopamine signaling and Huntington disease-related mechanisms.
Key Features
- Dopaminergic stabilizer with sigma-1 receptor relevance
- Modulates psychomotor activity in a state-dependent manner
- Useful for studying dopamine pathway normalization
- Relevant to Huntington disease and movement-disorder pharmacology
Applications
- Sigma-1 receptor pharmacology
- Huntington disease model research
- Dopamine D2 pathway studies
- Motor behavior and neurodegeneration assays
More Information
| Parent CAS No. | 346688-38-8 |
|---|---|
| Chemical Name | 4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride |
| SMILES | C1(S(C)(=O)=O)C=C(C2CCN(CCC)CC2)C=CC=1.Cl |
| MFCD | MFCD16038161 |
| InChi | InChI=1S/C15H23NO2S.ClH/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18;/h4-6,12-13H,3,7-11H2,1-2H3;1H |
| InChiKey | YGRHOYQMBLLGEV-UHFFFAOYSA-N |
| CID | 45378044 |
| Short Description | Dopaminergic stabilizer |
References
- H Ponten et al. In vivo pharmacology of the dopaminergic stabilizer pridopidine. Eur J Pharmacol. 2010 Oct 10;644(1-3):88-95.
- F Pettersson et al. Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer ... (huntexil, pridopidine, ACR16). J Med Chem. 2010 Mar 25;53(6):2510-20.
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