LBH 589 - NVP-LBH 589 | Panobinostat

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1548

CAS [404950-80-7]

MF C21H23N3O2
MW 349.43

  • Purity: 98%
  • Soluble in DMSO

LBH 589

Description

Highly potent and oral inhibitor of histone deacetylase (HDAC) with IC50 of HDAC1 to be 0.23 nM; an investigational drug against human pancreatic cancer, T cell lymphoma and other types of malignant diseases. In vitro LBH 589 induces cell cycle arrest and apoptosis through both caspase dependent and caspase independent pathways in various tumor cell types at nanomolar concentrations. In vivo LBH 589 inhibits tumor angiogenesis as evidenced by blocking new blood vessel formation in human prostate carcinoma cell PC 3 xenografts

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Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €235.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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