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BIBW 2992
- Afatinib
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25ClFN5O3
- MW: 485.94
Description
BIBW 2992 (Afatinib) is an irreversible ErbB-family tyrosine kinase inhibitor targeting EGFR/ErbB1 and HER2/ErbB2 signaling.
ErbB receptor networks drive proliferation and survival in lung, breast and other epithelial cancer models. BIBW 2992 is relevant for studying covalent EGFR/HER2 inhibition, receptor-network feedback and resistance to HER-family-targeted therapies.
Key Features
- Irreversible EGFR and HER2 kinase inhibitor
- Blocks HER-family receptor signaling
- Relevant to EGFR-mutant and HER2-driven cancer biology
- Useful for studying covalent ErbB inhibition and resistance
Applications
- EGFR and HER2 pathway research
- Non-small cell lung cancer models
- ErbB kinase inhibitor profiling
- Resistance and combination-treatment studies
More Information
| Parent CAS No. | 850140-72-6 |
|---|---|
| Chemical Name | (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| MFCD | MFCD12407405 |
| Short Description | EGFR/HER2 inhibitor |
References
- N Minkovsky and A Berezov. BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr. Opin. Investig. Drugs 2008, 9(12), 1336–46.
- D Li et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008, 27, 4702–4711.
- C Campas et al. BIBW-2992. Dual EGFR/HER2 inhibitor, oncolytic. Drugs Fut. 2008, 33(8), 649.
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