BI 6727 - Volasertib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1473

CAS [755038-65-4]

MF C34H50N8O3
MW 618.81

Purity: 99%
Optical purity: Optically pure
Moderately soluble in DMSO

BI 6727

Description

A highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines), which exhibited significant anti-proliferative in multiple cancer models, including a model of taxane-resistant colorectal cancer. A high volume of distribution, indicating good tissue penetration, and a long terminal half-life have emerged as distinct features of BI 6727, which may have a favorable effect on antitumor efficacy in vivo.

D Rudolph et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin. Cancer Res. 2009, 15(9), 3094-3102.

P Schöffski. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009, 14(6), 559-570.

PLK1 Inhibitor

Chemical name

N-((trans)-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-4-((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzamide

Parent CAS No.

[755038-65-4]

Order

Size	Unit Price	Stock
2 mg	€90.00	In Stock
5 mg	€125.00	In Stock
25 mg	€435.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€180.00	In Stock
2 x 25 mg	€640.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1129	BI 2536	PLK1 inhibitor		€60.00
1131	GW 843682X	PLK1 and PLK3 inhibitor		€85.00
1530	RO 3306	CDK1 inhibitor		€80.00
1585	Nutlin-3	MDM2 inhibitor (p53 specific)		€95.00
1597	Aurora A inhibitor I	Aurora A inhibitor		€125.00
1625	GSK579289A	PLK1 Inhibitor		€110.00
1626	GSK 461364 analogue II	PLK1 Inhibitor		€130.00
1630	Aurora A inhibitor II	Aurora A inhibitor		€125.00
1643	HLI 373	HDM2 inhibitor		€100.00
1688	GSK 461364	PLK1 inhibitor		€105.00
1880	Nutlin-3a	Inhibitor of MDM2		€95.00
1881	Nutlin-3b	Less potent (+)-enantiomer of Nutlin-3		€90.00
1904	SMER 3	Inhibitor of an SCF family E3 Ubiquitin ligase		€90.00
1910	MLN0905	PLK1 inhibitor		€95.00
1953	PRT 4165	E3 Ubiquitin ligase Bmi1/Ring1A inhibitor		€70.00
1961	MK 5108	Inhibitor of Aurora A kinase		€110.00
2003	MLN8237	Second generation selective Aurora A inhibitor		€90.00
2008	Tenovin 1	Activates p53 through inhibition of SIRT 1 and 2		€70.00
2009	RITA	Activates p53 through inhibition of MDM2		€105.00
2164	SJ 172550	Small molecule inhibitor of MDMX		€95.00
2249	Tenovin 6	Small water soluble p53 activator and SIRT inhibitor		€105.00
2437	SP 141	Specific MDM2 inhibitor with therapeutic effects in breast cancer models		€120.00
1538	JNJ 26854165	HDM2 inhibitor		€105.00
1586	JNJ 26854165 dihydrochloride	HDM2 inhibitor		€105.00
2950	Rigosertib sodium	Non-ATP-competitive PLK1 inhibitor		€95.00
4007	NMS-1286937	Orally bioavailable PLK1 inhibitor		Inquire
4192	(S)-BI 2536	Dual PLK1/BRD4 bromodomain inhibitor		€170.00
3918	CZS-241 hydrochloride	Highly potent, selective, and orally available PLK4 inhibitor	Recently added	€160.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

BI 6727 - Volasertib

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

BI 6727 - Volasertib

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us