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(S)-(-)-7-Hydroxy-DPAT hydrochloride
- (S)-7-OH-DPAT
Axon 1014
- Parent CAS: 82730-73-2
- Optical Purity: 98% e.e.
- Soluble in water and DMSO
- MF: C16H25NO.HCl
- MW: 283.84
Description
(S)-(-)-7-Hydroxy-DPAT hydrochloride is the (S)-enantiomer of 7-Hydroxy-DPAT (Axon 1012) and is described as a dopamine D3 receptor agonist with lower activity than the more active (R)-(+)-7-OH-DPAT enantiomer (Axon 1013). It is useful as a stereochemical comparator in D3 receptor studies.
Enantiomerically defined dopamine ligands help distinguish receptor-mediated activity from stereochemistry-dependent potency and selectivity. (S)-(-)-7-Hydroxy-DPAT hydrochloride can be used alongside racemic or (R)-configured 7-OH-DPAT analogues to assess D3 receptor pharmacology.
Key Features
- Dopamine D3 receptor agonist
- Less active enantiomer of 7-OH-DPAT
- Useful stereochemical comparator
- Activates dopamine D3 receptor-mediated signaling
Applications
- D3 receptor pharmacology
- Enantiomer comparison studies
- Dopamine receptor subtype assays
- Structure-activity relationship research
More Information
| Parent CAS No. | 82730-73-2 |
|---|---|
| Chemical Name | (S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrochloride |
| SMILES | C1(O)C=C2C[C@@H](N(CCC)CCC)CCC2=CC=1.Cl |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H25NO.ClH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H/t15-;/m0./s1 |
| InChiKey | PMBGJJRWBJWNTG-RSAXXLAASA-N |
| CID | 54582713 |
| Short Description | D3 agonist |
References
- G Damsma et al. Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 ligand. Eur. J. Pharmacol. 1993, 249, R9-R10.
- LM Pritchard et al. 7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment. Neuropsychopharmacology 2003, 28, 100–107.
- Seeman and Van Tol. Dopamine receptor pharmacology. TiPS 1994, 15, 264.
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