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Apatinib
- Apatinib mesylate - YN968D1 - Rivoceranib mesylate
- Parent CAS: 811803-05-1
- Soluble in DMSO
- MF: C25H27N5O4S
- MW: 493.58
Description
Potent and selective inhibitor of VEGFR2 tyrosine kinase (IC50 value of 1 nM). Apatinib could also potently suppress the activities of RET, c-KIT and c-Src with IC50 values of 0.13, 0.429 and 0.53 μM, respectively. In vivo, apatinib alone and in combination with chemotherapeutic agents effectively inhibited the growth of several established human tumor xenograft models with little toxicity.
More Information
| Parent CAS No. | 811803-05-1 |
|---|---|
| Chemical Name | N-(4-(1-cyanocyclopentyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide mesylate |
| SMILES | C1CC(C#N)(C2C=CC(NC(C3C(NCC4C=CN=CC=4)=NC=CC=3)=O)=CC=2)CC1.S(O)(C)(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;1-5(2,3)4/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H3,(H,2,3,4) |
| InChiKey | FYJROXRIVQPKRY-UHFFFAOYSA-N |
| CID | 45139106 |
| Short Description | VEGFR2 inhibitor |
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