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BMS 605541
- Soluble in DMSO
- MF: C19H17F2N5OS
- MW: 401.43
Description
BMS 605541 is potent, selective, orally active, ATP-competitive inhibitor of VEGFR2 (IC50 value of 23 nM). Orally active in human lung (L2987) and colon (HCT-116) carcinoma xenograft models at multiple dose levels.
More Information
| Parent CAS No. | 639858-32-5 |
|---|---|
| Chemical Name | N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide |
| SMILES | C1(F)C=C(F)C(C(=O)NC2CC2)=CC=1NCC1SC(NC2C=CC=CN=2)=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26) |
| InChiKey | CUPLTRAPYIXFAX-UHFFFAOYSA-N |
| CID | 11632737 |
| Short Description | VEGFR2 inhibitor |
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