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Sonepiprazole hydrochloride
- PNU 101387
Axon 2115
- Parent CAS: 170858-33-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C21H27N3O3S.HCl
- MW: 437.98
Description
Selective dopamine D4 antagonist; Displayed high affinity (Ki = 10 nM) and selectivity for the D4 receptor expressed in clonal cell lines, lacking measurable affinity for other dopamine receptors, and noradrenalin, serotonin and histamine receptor families (Ki > 2000 nM)
More Information
| Parent CAS No. | 170858-33-0 |
|---|---|
| Chemical Name | (S)-4-(4-(2-(isochroman-1-yl)ethyl)piperazin-1-yl)benzenesulfonamide hydrochloride |
| extra_info | . |
| SMILES | C1(S(N)(=O)=O)=CC=C(N2CCN(CC[C@@H]3OCCC4=CC=CC=C43)CC2)C=C1.Cl |&1:14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H27N3O3S.ClH/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21;/h1-8,21H,9-16H2,(H2,22,25,26);1H/t21-;/m0./s1 |
| InChiKey | LMERFPJRWBLXAM-BOXHHOBZSA-N |
| CID | 91826499 |
| Short Description | D4 antagonist |
References
- PA Broderick et al. Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. J. Neural. Transm. 1998, 105(6-7), 749-767.
- KM Merchant et al. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J. Pharmacol. Exp. Ther. 1996, 279(3), 1392-1403.
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