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CP 226269
Axon 1521
CAS:
220941-93-5
Purity:
99%
- Soluble in DMSO
- MF: C18H19FN4
- MW: 310.37
Description
CP 226269 is a selective dopamine D4 receptor agonist used to investigate D4-mediated dopaminergic signaling in the brain.
Dopamine D4 receptors are implicated in cognition, attention, limbic signaling and neuropsychiatric pharmacology. CP 226269 is useful for distinguishing D4 receptor effects from broader D2-like receptor activation in cellular and CNS research models.
Key Features
- Selective dopamine D4 receptor agonist
- Tool compound for D4-mediated signaling studies
- Supports analysis of D4 versus other D2-like receptor effects
- Relevant to cognition and neuropsychiatric pathway research
Applications
- Dopamine D4 receptor pharmacology
- CNS receptor activation assays
- Prefrontal and limbic dopamine signaling studies
- Neuropsychiatric model research
More Information
| Parent CAS No. | 220941-93-5 |
|---|---|
| Chemical Name | 5-Fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indole |
| SMILES | C1(F)C=C2C=C(CN3CCN(C4C=CC=CN=4)CC3)NC2=CC=1 |
| MFCD | MFCD07363967 |
| InChi | InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2 |
| InChiKey | PQOIDBZLMJMYCD-UHFFFAOYSA-N |
| CID | 9796720 |
| Short Description | D4 agonist |
References
- A Sharma et al. D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Mol. Psychiatry 1999, 4(3), 235–46.
- AM Basso et al. Antidepressant-like effect of D2/3 receptor-, but not D4 receptor-activation in the rat forced swim test. Neuropsychopharmacol. 2005, 30(7), 1257–68.
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