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L-655,708
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C18H19N3O4
- MW: 341.36
Description
L-655,708 is a selective inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (GABAA-α5) receptor with a Ki value of 0.45 nM.
More Information
| Parent CAS No. | 130477-52-0 |
|---|---|
| Chemical Name | (S)-Ethyl 7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate |
| SMILES | C1C=C2N3C=NC(C(OCC)=O)=C3[C@]3([H])CCCN3C(=O)C2=CC=1OC |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| InChiKey | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| CID | 5311203 |
| Short Description | GABAA-α5 agonist |
References
- K Quirk et al. [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit. Neuropharmacology. 1996;35(9-10):1331-5.
- T Gao et al. L-655,708 Does not Prevent Isoflurane-induced Memory Deficits in Old Mice. Transl Neurosci. 2019 Aug 7;10:180-186.
- JR Atack et al. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology. 2006 Nov;51(6):1023-9.
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