L-655,708

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3390

CAS [130477-52-0]

MF C18H19N3O4
MW 341.36

Purity: 99%
Optical purity: 100% e.e.
Soluble in DMSO

L-655,708

Description

L-655,708 is a selective inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (GABAA-α5) receptor with a Ki value of 0.45 nM.

K Quirk et al. [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit. Neuropharmacology. 1996;35(9-10):1331-5.

T Gao et al. L-655,708 Does not Prevent Isoflurane-induced Memory Deficits in Old Mice. Transl Neurosci. 2019 Aug 7;10:180-186.

JR Atack et al. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology. 2006 Nov;51(6):1023-9.

Selective inverse agonist of GABAA-α5

Chemical name

(S)-Ethyl 7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate

Parent CAS No.

[130477-52-0]

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