Bulk Inquiry
Nepafenac
- Soluble in DMSO
- MF: C15H14N2O2
- MW: 254.28
Description
Nepafenac is a prodrug of Amfenac. Nepafenac exhibited only weak COX-1 inhibitory activity (IC50 value of 64.3 μM). However, Amfenac was a potent inhibitor of both COX-1 (IC50 value 0.25 μM) and COX-2 activity (IC50 value of 0.15 μM). NSAID.
More Information
| Parent CAS No. | 78281-72-8 |
|---|---|
| Chemical Name | 2-(2-Amino-3-benzoylphenyl)acetamide |
| SMILES | C1C=C(CC(=O)N)C(N)=C(C(C2C=CC=CC=2)=O)C=1 |
| MFCD | MFCD08067732 |
| InChi | InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) |
| InChiKey | QEFAQIPZVLVERP-UHFFFAOYSA-N |
| CID | 151075 |
| Short Description | COX inhibitor |
References
- MA Kalin et al. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Inflammation. 2003 Oct;27(5):281-91.
- DA Gamache et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000 Aug;24(4):357-70.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1523 | Pravadoline |
From $77.00 |
| 1919 | Celecoxib |
From $55.00 |
| 1974 | GW 406381 |
From $132.00 |
| 2106 | Valdecoxib |
From $88.00 |
| 2108 | SC 236 |
From $88.00 |
| 2288 | ATB 346 |
From $121.00 |
| 3126 | Flurbiprofen |
From $55.00 |
| 3176 | Diethylcarbamazine citrate |
From $55.00 |
| 3311 | Parecoxib sodium |
From $55.00 |
| 3318 | Indomethacin |
From $55.00 |
| 3364 | Naproxen sodium |
From $55.00 |
| 3376 | Rofecoxib |
From $66.00 |
| 3448 | Diflunisal |
From $55.00 |
| 3712 | Isoxicam |
From $55.00 |
| 3818 | Oxaprozin |
From $88.00 |
