C19 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 1.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.

NMDAR-TRPM4 blocker C8 is available as Axon 3348.

KEYWORDS: C19 | supplier | NMDAR/TRPM4 inhibitor | FMP-A-02 | Aliudanexin | CAS [2241128-93-6] | [1456994-27-6] | [2031688-95-4] | Glutamate | NMDA | Inhibitor | Ion Channels | Stroke | Traumatic brain injury | Alzheimer’s disease | Huntington’s disease | Amyotrophic lateral sclerosis | Retinal degeneration | Neuroprotectant