NMDAR-TRPM4 blocker C19 dihydrochloride - FMP-A-02 | Aliudanexin

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Axon 3349

CAS [2241128-93-6]

MF C13H16Cl3N3O.2HCl
MW 409.57

  • Purity: 99%
  • Soluble in water and DMSO
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NMDAR-TRPM4 blocker C19 dihydrochloride

Description

C19 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 1.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.

NMDAR-TRPM4 blocker C8 is available as Axon 3348.

KEYWORDS: C19 | supplier | NMDAR/TRPM4 inhibitor | FMP-A-02 | Aliudanexin | CAS [2241128-93-6] | [1456994-27-6] | [2031688-95-4] | Glutamate | NMDA | Inhibitor | Ion Channels | Stroke | Traumatic brain injury | Alzheimer’s disease | Huntington’s disease | Amyotrophic lateral sclerosis | Retinal degeneration | Neuroprotectant

NMDAR/TRPM4 interaction interface inhibitor

Chemical name

2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride

Parent CAS No.

[1456994-27-6]

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10 mg €130.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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