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NMDAR-TRPM4 blocker C19 dihydrochloride
- FMP-A-02 - Aliudanexin
- Parent CAS: 1456994-27-6
- Soluble in water and DMSO
- MF: C13H16Cl3N3O.2HCl
- MW: 409.57
Description
C19 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 1.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.
NMDAR-TRPM4 blocker C8 is available as Axon 3348.
More Information
| Parent CAS No. | 1456994-27-6 |
|---|---|
| Chemical Name | 2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride |
| SMILES | C1(Cl)C=C(Cl)C(NC(=O)CN2CC(CN)CC2)=CC=1Cl.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C13H16Cl3N3O.2ClH/c14-9-3-11(16)12(4-10(9)15)18-13(20)7-19-2-1-8(5-17)6-19;;/h3-4,8H,1-2,5-7,17H2,(H,18,20);2*1H |
| InChiKey | KKZAEWKBOQYGHO-UHFFFAOYSA-N |
| CID | 138039902 |
| Short Description | NMDAR/TRPM4 inhibitor |
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