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NMDAR-TRPM4 blocker C8 dihydrochloride
- FMP-A-01 - Brophenexin
- Parent CAS: 1353979-43-7
- Soluble in water and DMSO
- MF: C11H17BrN2.2HCl
- MW: 330.09
Description
C8 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 2.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.
NMDAR-TRPM4 blocker C19 is available as Axon 3349.
More Information
| Parent CAS No. | 1353979-43-7 |
|---|---|
| Chemical Name | N1-(3-Bromobenzyl)-N1-ethylethane-1,2-diamine dihydrochloride |
| SMILES | C1C=CC(Br)=CC=1CN(CC)CCN.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C11H17BrN2.2ClH/c1-2-14(7-6-13)9-10-4-3-5-11(12)8-10;;/h3-5,8H,2,6-7,9,13H2,1H3;2*1H |
| InChiKey | AQDSZKTVQVSVNC-UHFFFAOYSA-N |
| CID | 138040845 |
| Short Description | NMDAR/TRPM4 inhibitor |
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