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CC-885
- Soluble in DMSO
- MF: C22H21ClN4O4
- MW: 440.88
Description
CC-885 is a cereblon (CRBN) modulator and molecular glue degrader that exhibits potent antitumor activity. It works by binding to cereblon (CRBN) to promote the selective ubiquitination and degradation of specific proteins, most notably the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines.
CC-885 serves as a vital chemical probe to validate oncology mechanisms across biochemical assays, cell screens, and translational disease-model platforms.
Key Features
- CRBN modulator and molecular glue degrader
- Acts by binding CRBN and altering its surface to trap and polyubiquitinate neo-substrates
- Specifically forces the proteasomal destruction of GSPT1
- Displays powerful anti-proliferative activity and induces apoptosis in patient-derived AML tumor cells
Applications
- Benchmarking Molecular Glues for Targeted Protein Degradation (TPD)
- Efficacy Testing in Solid Tumor Oncology
- Disease-model research related to AML
- Translation Termination Probing
More Information
| Parent CAS No. | 1010100-07-8 |
|---|---|
| Chemical Name | 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea |
| SMILES | N(C1=CC=C(C)C(Cl)=C1)C(NCC1C=CC2=C(C=1)CN(C1CCC(=O)NC1=O)C2=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21ClN4O4/c1-12-2-4-15(9-17(12)23)25-22(31)24-10-13-3-5-16-14(8-13)11-27(21(16)30)18-6-7-19(28)26-20(18)29/h2-5,8-9,18H,6-7,10-11H2,1H3,(H2,24,25,31)(H,26,28,29) |
| InChiKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
| CID | 24788636 |
| Short Description | Cereblon (CRBN) modulator |
References
- T Ito et al. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int J Hematol. 2016 Sep;104(3):293-9.
- ME Matyskiela et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7.
- Y Hu et al. Molecular glue degrader for tumor treatment. Front Oncol. 2024 Dec 12;0(0):1512666.
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