AMG 232

Based on 236 reference(s) in Google Scholar 8 10 236

Axon 2639

CAS [1352066-68-2]

MF C28H35Cl2NO5S
MW 568.55

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in 0.1N NaOH(aq) and DMSO

AMG 232

Description

Potent, selective, and orally bioavailable MDM2-p53 inhibitor (IC50 value 9.1 nM, Kd 0.045 nM), demonstrating remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model. Moreover, AMG 232 activates p53 pathway activity in vivo, and potentiates the activity of p53-inducing cytotoxic agents.

KEYWORDS: AMG 232 | supplier | MDM2 inhibitor | AMG232 | AMG-232 | CAS [1352066-68-2] | Axon Medchem | Axon 2639 | p53 | HDM-MDM | orally bioavailable | MDM2-p53 interaction | antitumor activity | SJSA-1 | osteosarcoma | xenograft model | p21

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Size Unit Price Stock
5 mg €115.00 In Stock
25 mg €385.00 In Stock
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2 x 5 mg €180.00 In Stock
2 x 25 mg €620.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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