Bulk Inquiry
Siremadlin
- NVP-HDM201 - HDM-201
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C26H24Cl2N6O4
- MW: 555.41
Description
Siremadlinis an orally bioavailable, potent and selective inhibitor of p53-MDM2 interaction, binding to human MDM2 protein with a picomolar Ki value (0.21 nM). Highly selective against MDM4 protein (Ki = 3300 nM, >10000 fold selectivity). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
More Information
| Parent CAS No. | 1448867-41-1 |
|---|---|
| Chemical Name | (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one |
| SMILES | C12[C@H](C3C=CC(Cl)=CC=3)N(C3C(=O)N(C)C=C(Cl)C=3)C(=O)C=1N=C(C1C=NC(OC)=NC=1OC)N2C(C)C |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1 |
| InChiKey | AGBSXNCBIWWLHD-FQEVSTJZSA-N |
| CID | 71678098 |
| Short Description | MDM2 inhibitor |
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