RG-7388
- Idasanutlin - RO5503781
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C31H29Cl2F2N3O4
- MW: 616.48
Description
RG7388 is an orally active, potent and selective inhibitor of the P53-MDM2 interaction with Ki at low nM. It binds to the MDM2 protein with a higher potency and selectivity, and has substantially improved pharmacological properties and superior clinical efficacy at lower dose. It is a second generation P53-MDM2 inhibitor under clinical investigation.
More Information
| Parent CAS No. | 1229705-06-9 |
|---|---|
| Chemical Name | 4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N1[C@@H](CC(C)(C)C)[C@@](C2C(F)=CC(Cl)=CC=2)(C#N)[C@@H](C2C=CC=C(Cl)C=2F)[C@@H]1C(=O)NC1C=CC(C(=O)O)=CC=1OC |&1:1,7,18,27,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C31H29Cl2F2N3O4/c1-30(2,3)14-24-31(15-36,19-10-9-17(32)13-21(19)34)25(18-6-5-7-20(33)26(18)35)27(38-24)28(39)37-22-11-8-16(29(40)41)12-23(22)42-4/h5-13,24-25,27,38H,14H2,1-4H3,(H,37,39)(H,40,41)/t24-,25-,27+,31-/m0/s1 |
| InChiKey | TVTXCJFHQKSQQM-LJQIRTBHSA-N |
| CID | 53358942 |
| Short Description | MDM2 antagonist |
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