DS-3032
- Milademetan - DS-3032B
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C30H34Cl2FN5O4
- MW: 618.53
Description
DS-3032 (Milademetan) is an orally available, potent and selective inhibitor of the p53-MDM2 (murine double minute 2) interaction.
More Information
| Parent CAS No. | 1398568-47-2 |
|---|---|
| Chemical Name | (3'R,4'S,5'R)-N-((3R,6S)-6-Carbamoyltetrahydro-2H-pyran-3-yl)-6''-chloro-4'-(2-chloro-3-fluoro-4-pyridinyl)-4,4-dimethyl-2''-oxo-1'',2''-dihydrodispiro(cyclohexane-1,2'-pyrrolidine-3',3''-indole)-5'-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C2([C@@]3(C(=O)NC4C=C(Cl)C=CC=43)[C@@H](C3C=CN=C(Cl)C=3F)[C@H](C(=O)N[C@@H]3CC[C@@H](C(=O)N)OC3)N2)CCC(C)(C)C1 |&1:2,13,22,26,29,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H34Cl2FN5O4/c1-28(2)8-10-29(11-9-28)30(18-5-3-15(31)13-19(18)37-27(30)41)21(17-7-12-35-24(32)22(17)33)23(38-29)26(40)36-16-4-6-20(25(34)39)42-14-16/h3,5,7,12-13,16,20-21,23,38H,4,6,8-11,14H2,1-2H3,(H2,34,39)(H,36,40)(H,37,41)/t16-,20+,21+,23-,30-/m1/s1 |
| InChiKey | RYAYYVTWKAOAJF-QISPRATLSA-N |
| CID | 73297272 |
| Short Description | MDM2 inhibitor |
References
- MM Gounder et al. Milademetan, an oral MDM2 inhibitor, in well-differentiated/dedifferentiated liposarcoma: results from a phase 1 study in patients with solid tumors or lymphomas. Eur J Cancer 138S2, 2020, S1–S62.
- V Arnhold et al. Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Oncotarget. 2017 Dec 18;9(2):2304-2319.
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