Amuvatinib - MP 470

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2368

CAS [850879-09-3]

MF C23H21N5O3S
MW 447.51

  • Purity: 99%
  • Soluble in DMSO



RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met (IC50 values low µM range in vivo). Amuvatinib influences various survival and DNA repair related proteins such as pAKT, RAD51 and GSK-3β, inhibits cell proliferation, induces cell growth arrest and promotes apoptosis in prostate LNCaP cancer cells with low μM IC50 values. When combined with Erlotinib (Axon 1128), Amuvatinib abolished HER family/PI3K/Akt pathway with associated tumor growth inhibition in prostate cancer.

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10 mg €105.00 In Stock
50 mg €365.00 In Stock
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2 x 10 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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