NS 19504

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2329

CAS [327062-46-4]

MF C10H9BrN2S
MW 269.16

  • Purity: 99%
  • Soluble in DMSO

NS 19504

Description

Potent activator of large-conductance Ca2+-activated potassium channels (BK, KCa1.1, MaxiK; EC50 value 11 µM in a Tl+ assay) with a favorable selectivity profile in a screen of 68 receptors and by functional tests on Nav, Cav, SK, and IK channels. NS19504 potently inhibits urinary bladder spontaneous phasic contractions (SPCs) while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. At a concentration of 10 µM, NS19504 was also found to inhbit the σ1 receptor, two transporters of neurotransmiters (DA and Norepinephrine), and soluble epoxide hydrolase (sEH).
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Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €320.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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