NS 19504

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2329

CAS [327062-46-4]

MW 269.16

  • Purity: 99%
  • Soluble in DMSO

NS 19504


Potent activator of large-conductance Ca2+-activated potassium channels (BK, KCa1.1, MaxiK; EC50 value 11 µM in a Tl+ assay) with a favorable selectivity profile in a screen of 68 receptors and by functional tests on Nav, Cav, SK, and IK channels. NS19504 potently inhibits urinary bladder spontaneous phasic contractions (SPCs) while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. At a concentration of 10 µM, NS19504 was also found to inhbit the σ1 receptor, two transporters of neurotransmiters (DA and Norepinephrine), and soluble epoxide hydrolase (sEH).
Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €320.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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